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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

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Full methodological details of BE OPTIMAL (ClinicalTrials.gov: NCT03895203) and BE COMPLETE (NCT03896581) are reported in the primary manuscripts, including key inclusion and exclusion criteria