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Much remains unknown about the health affects of vaping, but health officials say there are already disturbing signs that e-cigarettes may not be safe

14) that can signal the release of neurotransmitters such as dopamine, norepinephrine, acetylcholine, GABA, and glutamate involved in reward pathways, transmission at the neuromuscular junction, and cognition (Figures 2, 3) [Figure 2) [ FIGURE 2 FIGURE 3 Brain imaging studies have demonstrated that nicotine acutely increases the activity in the visual system, PFC, and thalamus which are consistent with activation of the corticobasal ganglia-thalamic brain circuits [Figure 4) [ FIGURE 4 While electronic cigarettes (e-cigarettes) do not produce combusted smoke, they do deliver an aerosol containing nicotine and other tobacco-related compounds [26]

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Cigarette smoking dropped to another new all-time low last year, but e-cigarette use rose, to about 1 in 17 adults