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Importantly, combination experiments in animals provided early evidence of synergy: animals treated with both a GLP-1 analogue (such as ecnoglutide, an experimental GLP-1 RA) and an amylin analogue lost markedly more weight than those treated with either agent alone, far exceeding additive expectationsbiospace.combiospace.com

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The S-acetyl molecule bound to glutathione protects glutathione from breaking down in the gastrointestinal tract, so it reaches the bloodstream intact