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The shRNA constructs against NRF2 were designed targeting guggcugcucagaauugcaga (sh NRF2 -1), guaagaagccagauguuaaga (sh NRF2 -2), and gcuccuacugugaugugaaau (sh NRF2 -3) (#230086 and 230087, Addgene)

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Because of all of these mechanisms, it explains why its been used in traditional and modern medicine for so many different diseases and conditions, from asthma and upper respiratory infections to autoimmune disease to cognitive and mood disorders to metabolic and cardiovascular disease to cancer