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Interestingly, systemic inflammation has a somewhat opposite effect on microglia-BBB interactions, as initially microglia respond to systemic inflammation by maintaining BBB integrity through direct interactions with endothelial cells

The meta-analysis results showed that ESWT significantly reduced MAS score compared to control (MD -0.65, 95%CI [-1.36, -0.29], P = 0.0005)

It also accelerates wound healing by promoting angiogenesis and recruiting immune cells to injury sites, which reduces scarring

REDEFINE 2 (combination, with type 2 diabetes) In adults with type 2 diabetes, the combination achieved 13.7% weight reduction versus 3.4% for placebo