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When topical treatments alone are insufficient, oral antibiotic treatment becomes the next step

Cell 46 , 113 (2012)

No cell-related safety issues were encountered in this trial, although the patients receiving 18*10 6 MSCs showed a higher incidence of adverse effects ( Lastly, several human growth factor-based phase I/II clinical trials were started to evaluate the safety, tolerability, and preliminary effectiveness of intradiscal delivery of growth and differentiation factor-5 (GDF-5) as compared with placebo (sterile water/vehicle control) in human patients with early lumbar disc degeneration in the United States, Australia, and the Republic of Korea

At the plasma membrane, the oligopeptide transporter (OPT) mediates GSH translocation [85,86]