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Regulatory diversity affects product flow and availability across both regions

The tax differential is why cross-border cigarette purchasing (buying in low-tax states for use in high-tax states) is a persistent behavior despite being technically illegal for personal importation above personal-use quantities

Luminex analyses of fresh blood samples revealed a trend towards higher levels of IL-1, G-CSF, IL-1RA, IL-4, MIP1, IL-8 and IL-6 in smokers but this reached statistical significance only with IL-6

It is hoped the higher prices will convince smokers to quit, although there are fears it could just drive many to engage in cross-border shopping or purchase from the illicit tobacco market