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According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

Polystyrene microplastics are internalized by ovarian granulosa cells, inducing pyroptosis via OS-mediated NLRP3/caspase-1 activation (Hou et al., 2021)

Authors of the latter study reported further increase of sperm density on subsequent visits, and 2 pregnancies within 3 months

Goldfish somatotrophs express GnRH receptors (225, 226)