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Dihexa is reported to be active at picomolar concentrations in synaptogenesis assaysapproximately 10,00010,000,000-fold more potent than BDNF (brain-derived neurotrophic factor) in some in vitro measures, though this comparison involves different assay conditions and should not be taken as a direct clinical equivalence claim

[Abstract]2025 Apr 23

Activation of vitamin B2 in the body requires all of Iodine, Selenium and/or Molybdenum, and at the top of this cascade is the requirement for an active thyroid