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POI, formerly known as premature ovarian failure, is characterized by menstrual cycle disruptions and the loss of ovarian function before the age of 40

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Consistent with the transcriptomic findings, proteomic analysis of liver from Gclc KO mice revealed that most significantly elevated proteins in Gclc KO liver were encoded by NRF2 target genes, including the canonical NRF2 target NQO1 (NAD(P)H Quinone Dehydrogenase 1) (Fig

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