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Also multivariable Cox proportional hazard regression analyses were performed to estimate the hazards ratio (HR) and 95% confidence interval (CI) of incident T2D in subgroups of sex, smoking and BMI

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NUDT1 hydrolyzes oxidized guanine in the nucleotide pool, thus preventing the misincorportation of 8-OH-dGTP opposite adenine during DNA replication, which produces A:TC:G transversion mutation ( see , Figure 2) [161, 162]