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doi:10.1016/j.amsu.2020.11.010

2016) and a mean decrease of 4.29 points over three months, compared to an increase of 2.36 in the control group (Monti et al

The isosteric replacement of sp 2 -heavy aromatic rings with sp 3 -rich small-ring cage hydrocarbon systems has emerged as a promising strategy towards improving the physicochemical and pharmacokinetic properties of drug candidates 25,26