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Hon Liks initial patent filing was submitted on April 14, 2004 (Publication Number: US8393331 B2)

A new perspective on constipation is provided by our study of serum cotinine levels, which are often used as a means of distinguishing smokers from non-smokers at the cutpoint of 3 ng/mL, and the promoting effect on stool frequency-related constipation may not appear in the general population but may appear when cotinine levels range between 0.05 and 2.99 ng/mL

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Smoking status should be routinely considered during patient consultations