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[DOI] [PubMed] [Google Scholar] 108.Hartog H., Van der Graaf W.T.A., Wesseling J., Van der Veer E., Boezen H.M

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Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine

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