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Three previous studies that found an increase in uncoupling protein (UCP2) expression [26, 73] and protein [31] in LCLs derived from children with ASD, particularly the AD-A LCLs [31]

For practical comparison: | Property | Native IGF-1 | IGF-1 DES | IGF-1 LR3 | |---|---|---|---| | Amino acids | 70 | 67 | 83 | | Half-life | ~10 min | ~20-30 min | ~20-30 h | | IGFBP-3 affinity | High | Low | Very low (~1,000x reduced) | | Relative IGF-1R potency | 1x | ~10x | ~2-3x | | Systemic vs

K., Alhhazmi, A., DeCoteau, J