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Brain metabolites are secreted and infiltrated into CSF to regulate the entire central nervous system and even organs throughout the entire body ( Recent research suggests that there is a class of neurons in contact with CSF on the ependyma called CSF-contacting neurons (CSF-cNs), and the location of CSF-cNs and ciliary morphology suggests that they sense physical and chemical signals in the CSF ( After TBI, CSF-cN iron-induced damage may be part of the reason why cognitive dysfunction develops

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Biochemical & Biophysical Research Communications 344:617-622