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Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

Furthermore, eight out of nine preclinical studies evaluated in this meta-analysis showed that a KD was able to slow down tumor growth, often even as a monotherapy

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