Abbreviations PDT: Photodynamic therapy OSCC: Oral squamous cell carcinoma CCM: Cancer-cell membrane TME: Tumor microenvironment HNSCC: Head and neck squamous cell carcinoma 5-OOH: 5-hydroperoxide GPX4: Glutathione peroxidase 4 Cho : Cholesterol alkoxyl radical MOFs: Metal-organic frameworks ROS: Reactive Oxygen Species TEM: Transmission electron microscopy XPS: X-ray photoelectron spectroscopy TGA: Thermogravimetric analysis FT-IR: Fourier transform infrared AFM : Atomic force microscopy FCM: Flow cytometry EDS: Energy-dispersive spectroscopy BET: BrunauerEmmettTeller BJH: Barret-Joyner-Halenda DFT: Density functional theory DLS: Dynamic light scattering POD-like: Peroxidase-like TMB: 3,3,5,5-tetramethylbenzidine oxTMB: Oxidized TMB MB: Methylene blue OH: Hydroxyl radicals CAT: Catalase SOSG: Singlet oxygen sensor green O: Singlet oxygen HOK: Human oral keratinocyte Bio-TEM: Bio-transmission electron microscopy CLSM: Confocal laser scanning microscopy WGA: Wheat germ agglutinin CTB: Cholera toxin subunit B LDH: Lactate dehydrogenase H&E: Hematoxylin and eosin mIHC: Multiplexed immunohistochemical References Cai Y, Chai T, Nguyen W, Liu J, Xiao E, Ran X, et al

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