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Here is what the evidence says, clearly and without exaggeration

(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

To produce these density solutions from OptiPrep and to mimic the EDTA profile of the Nycodenz gradient, first dilute OptiPrep with an equal volume of PBS to produce a 30% (w/v) iodixanol solution and then dilute further with PBS containing 4 mM EDTA to make solutions of 12%, 14.5%, 17.5% and 20% (w/v) iodixanol