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In addition to COMT , bipolar disorder has been associated with polymorphisms in a number of other genes coding for monoamine receptors, transporters, and synthetic and catabolic enzymes, including monoamine oxidase ( MAOA ), dopamine transporter ( DAT ), serotonin transporter ( 5HTT ), tryptophan hydroxylase ( TPH2 ), and the D2 , D4 , 5HT4 , and 5HT2A receptors (4245)

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Serum was isolated from whole blood by centrifugation at 4600g for 1h and stored at 80C prior to analysis