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GHK-Cu is best known for its broad influence on extracellular matrix biology, collagen turnover and gene regulation

As stress may incur an excess of glucocorticoids or reductions in neurotrophin levels which are thought to be associated with decreased astrocytic density and impaired astrocytic function, it may, in turn, lead to disruption of glutamatergic system and subsequent neurotoxicity The insults: Infection, chronic stress, trauma, drugs, etc

The upregulation of BDNF signaling in animal models appears to improve the survival of dopaminergic neurons when given prior to PD induction or result in partial restoration of dopaminergic transmission [230]

For patients with Wilsons disease or suspected Wilsons disease, any copper-containing therapy is contraindicated