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Continued efforts resulted in an analog characterized by increased hydrophobicity, decreased hydrogen bonding potential coupled with increased metabolic stability bonding potential, and significantly increased metabolic stability [69,72]

Representative experimental areas include: Metabolic disease and obesity: Murine models show that MOTS-C improves insulin sensitivity, enhances skeletal muscle glucose uptake, promotes lipid utilization, and reduces dietinduced obesity while improving glucose tolerance

It binds to toxins, making them more water-soluble and easier for the body to excrete

Constipation may develop as gastric emptying slows more noticeably