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MET is synthesized as a single-chain precursor, which is then cleaved into an , heterodimer by a protease of the furin family in the Golgi apparatus (Komada et al., 1993)

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Abstract Background Cobalamin (cbl)-related remethylation disorders are a heterogeneous group of inherited disorders comprising the remethylation of homocysteine to methionine and affecting multiple organ systems, most prominently the nervous system and the bone marrow

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