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RESULTS All of the NSAIDs induced both lower esophageal and pyloric sphincters pressure fall, and thereby the induced sphincter failure may be a common phenomenon of NSAIDs, with some particularities for the used non-specific (diclofenac, ibuprofen, aspirin, paracetamol) and specific (celecoxib) NSAIDs ( Figs
Common Side Effects The most frequently reported cagrilintide side effects include: Dose-Dependent Adverse Events Phase 2 trials clearly demonstrated that higher doses increase gastrointestinal side effects: At 2.4 mg weekly: Manageable nausea in most participants Side effects typically decrease after 4-8 weeks Discontinuation rates remain acceptable At 4.5 mg weekly: Significantly increased nausea and vomiting Higher treatment discontinuation rates Limited additional weight loss benefit This dose-response relationship explains why 2.4 mg was selected as the optimal maintenance dose
Over time, this loss of stability and lubrication can lead to damage of the articular cartilage and increase the risk of developing arthritis
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