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4ae), as well as neuronal apoptosis detected by cleaved-caspase-3 (Fig

The arginine substitution at position 3 and the N-terminal extension collectively reduce IGFBP affinity by approximately 1001,000-fold in preclinical binding assays

IL-1 treatment significantly increased ROS levels in ECs and markedly decreased mitochondrial membrane potential, as indicated by immunofluorescence staining

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