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The interactions of lipin-1 with PPAR and PGC-1 leads to increased expression of fatty acid oxidizing genes such as carnitine palmitoyltransferase-1 (CPT-1: encoded by the CPT1A gene), acyl-CoA oxidases (peroxisomal fatty acid oxidation pathway), and medium-chain acyl-CoA dehydrogenase (MCAD: encoded by the ACADM gene)

Thus, many key intracellular signaling events discovered in mice are reproducible in human hepatocytes suggesting that common mechanisms are in play during progression of APAP-induced liver injury

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