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This impairment has been postulated to be one of the mechanisms of a decreased hepatic GSH level (Mato et al., 1994)

Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats

Fluorescent staining of lesion tissue revealed normal structure and morphology, while immunohistochemistry showed decreased CD4 or T cell infiltration and reduced inflammatory responses