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Contraindications include pregnancy, lactation, allergies to the ingredients, skin infections, active herpes, severe acne, blood coagulation disorders, connective tissue diseases, and various other medical conditions

However, in the CNS, this process, termed neuroinflammation, differs fundamentally from peripheral inflammation

Apr 2003;169(4):1564-8

FIGURE 2 1.2.2 Compensatory physiological responses to hypoxia In response to the hypoxic challenge at high altitude, the body initiates several adaptive physiological responses: Respiratory System: By increasing respiratory rate and depth to enhance oxygen uptake and carbon dioxide elimination