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A critical mechanistic link between inflammation and depression involves activation of the indoleamine-2,3-dioxygenase (IDO) enzyme, which diverts tryptophan metabolism away from serotonin production toward the kynurenine pathway

Oral B12 supplements are absorbed at roughly 1 to 5% in healthy adults, and even less in people with low intrinsic factor, atrophic gastritis, or gut absorption issues

While some have been subject to clinical studies, none have been approved as prescription drugs

This finding was mechanistically supported by an enhanced antifungal effect of fluconazole in a VVC vaginal epithelial cell model and mouse model when administered together with vitamin B complex injection 81