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MC1R activation: Stimulates melanin production darker skin tone MC4R activation: Influences appetite and sexual function Effects build gradually with consistent dosing during the loading phase

The phosphorylated analogue P-DSIP has been reported to produce larger increases in slow-wave and paradoxical sleep than the parent peptide in unrestrained rats under continuous nocturnal infusion (Yehuda & Mostofsky, 1989)

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