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Endothelial cells line the inner layer of blood vessels that keep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive (e.g., vasorelaxing and vasoconstricting) molecules and are essential for maintaining tissue homeostasis ( The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 also reflect ED ( Endothelial cell integrity is significantly affected by the cytokine storm induced by COVID-19

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Acknowledgments All figure created in The authors would like to thank all the reviewers who participated in the review and MJEditor (www.mjeditor.com) for its linguistic assistance during the preparation of this manuscript