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The proposed mechanism of action that led originally to the consideration of IVIg as treatment is as follows: IVIg can act as a blocking antibody, which would interfere with the Fas ligand-induced keratinocyte apoptosis that underlies this cutaneous reaction

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5-FU has been approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as a therapeutic of sBCC along a dosage regimen of two times a day for two to four weeks