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People with the following should discuss risks carefully with a medical professional: Liver disease Kidney disease Pernicious anemia Known allergies to any ingredient in the formulation Pregnancy or breastfeeding (safety not well-studied avoid unless prescribed) Because ingredients differ between providers, always verify the formulation and follow prescribed dosing to minimize risk

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Various stimuli, including telomere dysfunction and oxidative stress, induce cellular senescence through the p53 and Rb proteins, and senescent cells can promote disorders associated with aging or age-related diseases