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State regulators attempting to address youth nicotine dependence and youth access to these products have faced increased difficulties, particularly because there are no nicotine concentration restrictions imposed by the FDA and nearly all new oral nicotine products are being marketed in an illegal fashion without FDA marketing authorization

Singer, NERC Centre for Ecology & Hydrology, UNITED KINGDOM Received: July 20, 2014

Moreover, a GABA system in the brainstem might have a previously unrecognized and prominent role in the rewarding effects of nicotine

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