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However, in many cases, the results from in vitro tests cannot be simply translated to in vivo conditions

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Alayash, SCD erythrocytes contain dysfunctional membrane channels, such as K-Cl cotransporters or Gardos channels, which contribute to cell dehydration, further increasing the HbS concentration and polymerisation (Frenette and Atweh, 2007

They naturally occur in the body and can also be used in therapeutic treatments for health optimization