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[PMC free article: PMC3842113] [PubMed: 23390034] (Testing plasma from 129 patients presenting after an acute acetamenophen overdose [with levels that warranted acetylcysteine therapy] showed elevations in miR-122, HMGB1 and K18 well before rises in ALT, which were predictive of subsequent liver injury and thus early, prognostic markers)

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Upon entry into the cell, foreign bacterial, viral, or mitochondrial RNA activates the innate immune response via several molecular cascades