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Packages of Extra Strength Tylenol now contain the warning: Acetaminophen overdose is one of the most common poisonings worldwide according to the National Institutes of Health

Inhibiting IDO1, one of the key enzymes involved in tumor immune escape, reduces the functional suppression of T cells by tumors and improves the effector function of immune cells in the tumor microenvironment

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iTRAQ samples were tryptically digested by using a FASP Protein Digestion Kit (Protein Discovery, San Diego, CA) according to the manufacturers instructions with slight modifications (Supplemental Data), samples were desalted by C18 solid-phase extraction (SPE) before isobaric labeling (SUPELCO)