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The redox reaction within cells is facilitated by redox-active transition metals, including Fe, Cu, Cr, and Co (Kostenkova et al., 2022)

Flavonoids and isoflavones have minimal inhibitory effects on aromatase and 17-hydroxysteroid dehydrogenases (17-HSD) in breast cancer cells, and they also hinder the generation of active oestrogens & steroid synthesis within cancer cells (128)