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doi: 10.3390/antiox10050701

The epidemiological data on sex differences in acetaminophen-induced liver injury in humans is inconsistent, which can be attributed to confounding factors such as variations in age, dosage, time elapsed from ingestion to hospitalization, and time from ingestion to N-acetylcysteine administration

Intermediates of the TCA cycle such as -ketoglutaric acid and citrate typically show decreased levels, whereas succinate is upregulated in RA (45, 46)

Previous studies have shown that PGPIPN could play an important role in immune response in rats and mice, such as promoting macrophage phagocytosis and lymphocyte proliferation [14]