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Sometimes the inflammation is subtle and appears as puffiness around the knees, wrists, knuckles, or ankles

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Circadian Rhythm Regulation DSIP may play a role in regulating the bodys natural circadian rhythm, which governs sleep-wake cycles (4)

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This downregulation facilitated the dissociation of STIM1 from STING, thereby activating the non-canonical STING signaling pathway and enhancing autophagy in cortical neurons

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