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Doses used in ARA-290 human trials Study context Sarcoidosis pilot (2012) Dose & route 2 mg IV Schedule 3x/week, 4 weeks Study context Sarcoidosis SFN (2013) Dose & route Daily subQ Schedule 28 days Study context Type 2 diabetes neuropathy (2014) Dose & route 4 mg subQ Schedule Daily, 28 days Study context Phase 2b sarcoidosis (2017) Dose & route 1, 4, or 8 mg subQ Schedule Daily, 28 days Study context Diabetic macular edema (2020) Dose & route 4 mg subQ Schedule Daily, 12 weeks This is trial reporting, not a dosing recommendation

Fertility and Sterility, 106(7), e251-e256

250500 g once per day Duration: 46 weeks Because IM injections are more invasive, they should always be performed under professional supervision

It was tested on healthy volunteers and on a small cohort of patients with Crohns disease