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Shifts in the levels of multiple metabolites within a single pathway can provide more information about regulatory processes than changes within levels of a single metabolite

Importantly, P2X7 sits upstream from the majority of inflammatory signals mentioned throughout this review, theoretically providing a more advantageous target compared to conventional anti-inflammatory treatments

And this remarkable advance originated when, on a hunch, he mined published literature to better understand what was occurring in patients whose symptoms long outlasted the immediate effects of acute injury