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Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics

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In obese adipose tissue, excessive ROS production from NADPH oxidases and impaired ETCs induces mitochondrial DNA (mtDNA) damage, which escapes into the cytoplasm and circulation as damageassociated molecular patterns (DAMPs), activating TLR9 and NLRP3 inflammasome pathways to trigger proinflammatory cytokine cascades such as IL1 and IL18 [118, 119]

Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis